Promethazine HCl and Codeine Phosphate Oral Option need to be used with caution in sufferers with bone- marrow melancholy. Leukopenia and agranulocytosis are already reported, ordinarily when promethazine has long been used in Affiliation with other recognised marrow-toxic agents.
Slowed Gut Movement. Paralytic ileus is usually a variety of ileus where by your intestines are unable to shift food items by way of them. Promethazine/codeine might make this problem worse.
Allergy symptoms to Components. People who are allergic to any of the following shouldn't just take promethazine/codeine.
Antihistamines and codeine are both contraindicated for use within the cure of decrease respiratory tract indicators, together with asthma.
g., Those people with evidence of enhanced intracranial pressure or brain tumors), Promethazine HCl and Codeine Phosphate Oral Resolution may minimize respiratory drive, as well as resultant CO2 retention can additional raise intracranial strain. In addition, opioids deliver adverse reactions which will obscure the scientific system of individuals with head accidents.
Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Solution shouldn't be elevated if cough fails to reply; an unresponsive cough need to be reevaluated in five times or sooner for attainable underlying pathology, which include overseas human body or lower respiratory tract disease [see Dosage and Administration (two.3)].
Providing or giving freely Promethazine Hydrochloride and Codeine Phosphate Oral Alternative could damage others, and is particularly against the law. Tell your Health care supplier When website you have at any time abused or been depending on Liquor, prescription medicines or Avenue medicine.
If someone has overdosed and has major signs and symptoms for example passing out or difficulty respiratory, simply call 911. If not, contact a poison Handle Heart without delay.
Confined data here recommend that use of promethazine hydrochloride for the duration of labor and shipping doesn't have an appreciable effect more info on the duration of labor or delivery and will not enhance the risk of require for intervention inside the newborn.
Head Personal injury And Amplified Intracranial Tension: The Hi-Tech promethazine syrup respiratory-depressant outcomes of narcotic analgesics and their capability to elevate cerebrospinal fluid pressure may be markedly exaggerated in the existence of head injuries, intracranial lesions or even a preexisting increase in intracranial tension.
Due to the possible for promethazine to reverse epinephrine’s vasopressor outcome, epinephrine shouldn't be employed to take care of hypotension affiliated with promethazine overdose.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate, demanding mindful thought of the consequences around the mum or dad drug, codeine, and the active metabolite, morphine.
Codeine: Narcotic analgesics, together with codeine, exert their Principal consequences on the central nervous procedure and gastrointestinal tract. The analgesic outcomes of codeine are because of its central motion; having said that, the precise web pages of action haven't been established, and more info also the mechanisms associated seem like really sophisticated.
In An additional review a single one hundred-mg/kg dose of codeine administered to Expecting mice reportedly resulted in delayed ossification inside the offspring.